KEGG   DRUG: Telmisartan
Entry
D00627                      Drug                                   
Name
Telmisartan (JP18/USP/INN);
Micardis (TN)
Product
MICARDIS (Boehringer Ingelheim Pharmaceuticals)
  Generic
TELMISARTAN (A-S Medication Solutions), TELMISARTAN (A-S Medication Solutions), TELMISARTAN (Alembic Pharmaceuticals Limited), TELMISARTAN (Alembic Pharmaceuticals), TELMISARTAN (Amneal Pharmaceuticals LLC), TELMISARTAN (Amneal Pharmaceuticals of New York LLC), TELMISARTAN (Ascend Laboratories), TELMISARTAN (Aurobindo Pharma Limited), TELMISARTAN (AvKARE), TELMISARTAN (Bryant Ranch Prepack), TELMISARTAN (Bryant Ranch Prepack), TELMISARTAN (Bryant Ranch Prepack), TELMISARTAN (Bryant Ranch Prepack), TELMISARTAN (Bryant Ranch Prepack), TELMISARTAN (Cadila Pharmaceuticals Limited), TELMISARTAN (Chartwell RX), TELMISARTAN (Glenmark Pharmaceuticals), TELMISARTAN (Micro Labs Limited), TELMISARTAN (Modavar Pharmaceuticals LLC), TELMISARTAN (Mylan Pharmaceuticals), TELMISARTAN (NuCare Pharmaceuticals), TELMISARTAN (NuCare Pharmaceuticals), TELMISARTAN (PD-Rx Pharmaceuticals), TELMISARTAN (Preferred Pharmaceuticals), TELMISARTAN (Preferred Pharmaceuticals), TELMISARTAN (Proficient Rx LP), TELMISARTAN (REMEDYREPACK), TELMISARTAN (REMEDYREPACK), TELMISARTAN (REMEDYREPACK), TELMISARTAN (RPK Pharmaceuticals), TELMISARTAN (Solco Healthcare US), TELMISARTAN (Zydus Lifesciences Limited), TELMISARTAN (Zydus Pharmaceuticals USA), TELMISARTAN (medsource pharmaceuticals)
Formula
C33H30N4O2
Exact mass
514.2369
Mol weight
514.6169
Structure
Simcomp
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01495  Angiotensin II receptor antagonist
 DG03231  Antihypertensive
  DG01495  Angiotensin II receptor antagonist
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Same as: C07710
Therapeutic category: 2149
ATC code: C09CA07
Product: D00627<JP/US>
Product (mixture): D09219<JP/US> D09743<JP/US> D10805<JP>
Efficacy
Antihypertensive, Angiotensin II receptor antagonist
  Disease
Hypertension [DS:H01633]
Target
AGTR1 [HSA:185] [KO:K04166]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Structure map
map07229  Angiotensin receptor and endothelin receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
    C09CA Angiotensin II receptor blockers (ARBs), plain
     C09CA07 Telmisartan
      D00627  Telmisartan (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Telmisartan
    D00627  Telmisartan (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00627  Telmisartan (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01495  Angiotensin II receptor antagonist
    D00627  Telmisartan
  DG03231  Antihypertensive
   DG01495  Angiotensin II receptor antagonist
    D00627  Telmisartan
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   D00627  Telmisartan
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01495  Angiotensin II receptor antagonist
   D00627  Telmisartan
  DG03231  Antihypertensive
   D00627  Telmisartan
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    AGTR1
     D00627  Telmisartan (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00627  Telmisartan
  D00627  Telmisartan tablets
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00627
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00627
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00627
Other DBs
CAS: 144701-48-4
PubChem: 7847693
ChEBI: 9434
PDB-CCD: TLS[PDBj]
LigandBox: D00627
NIKKAJI: J556.167A
KCF data

ATOM        39
            1   C8x C     6.3000   -7.3500
            2   C8x C     6.3000   -8.7500
            3   C8x C     7.5124   -9.4500
            4   C8x C     8.7249   -8.7500
            5   C8y C     8.7249   -7.3500
            6   C8y C     7.5124   -6.6500
            7   C8y C     9.9560   -6.6390
            8   C8x C    11.1612   -7.3347
            9   C8x C    12.3735   -6.6346
            10  C8y C    12.3735   -5.2346
            11  C8x C    11.1683   -4.5389
            12  C8x C     9.9559   -5.2390
            13  C6a C     7.5124   -5.2502
            14  O6a O     6.2832   -4.5403
            15  O6a O     8.7080   -4.5598
            16  C1b C    13.5914   -4.5312
            17  N4y N    14.8034   -5.2307
            18  C8y C    15.2226   -6.5648
            19  C8y C    16.6225   -6.5780
            20  N5x N    17.0677   -5.2506
            21  C8y C    15.9428   -4.4171
            22  C1b C    15.9551   -3.0100
            23  C1b C    17.1773   -2.3185
            24  C1a C    18.3595   -3.0151
            25  C8x C    14.5112   -7.7706
            26  C8y C    15.1998   -9.0596
            27  C8x C    16.5998   -9.0027
            28  C8y C    17.3111   -7.7969
            29  C1a C    18.6894   -7.7394
            30  C8y C    14.5146  -10.2563
            31  N4y N    13.1146  -10.2563
            32  C1a C    12.4229   -9.0592
            33  C8y C    12.6819  -11.5878
            34  C8y C    13.8146  -12.4107
            35  N5x N    14.9472  -11.5878
            36  C8x C    13.8146  -13.8107
            37  C8x C    12.5931  -14.5162
            38  C8x C    11.3745  -13.8131
            39  C8x C    11.3745  -12.3904
BOND        44
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14    6  13 1
            15   13  14 2
            16   13  15 1
            17   10  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 2
            23   17  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   18  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   19  28 2
            32   28  29 1
            33   26  30 1
            34   30  31 1
            35   31  32 1
            36   31  33 1
            37   33  34 2
            38   34  35 1
            39   30  35 2
            40   34  36 1
            41   36  37 2
            42   37  38 1
            43   38  39 2
            44   39  33 1

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